Structure of PDB 1e5a Chain A

Receptor sequence
>1e5aA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTNP
3D structure
PDB1e5a Structure of Human Transthyretin Complexed with Bromophenols : A New Mode of Binding
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBP A K15 L17 K6 L8 MOAD: Kd=23nM
PDBbind-CN: -logKd/Ki=7.64,Kd=23nM
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:1e5a, PDBe:1e5a, PDBj:1e5a
PDBsum1e5a
PubMed10957627
UniProtP02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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