Structure of PDB 1e3g Chain A

Receptor sequence
>1e3gA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKW
AKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDL
VFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV
DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP
IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB1e3g Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R18 A L704 N705 Q711 M745 M749 F764 T877 M895 L36 N37 Q43 M77 M81 F96 T209 M227 PDBbind-CN: -logKd/Ki=9.00,Kd=0.99nM
BindingDB: Kd=0.99nM,IC50=0.302000nM,EC50=0.013000nM,Ki=0.400000nM
External links
PDB RCSB:1e3g, PDBe:1e3g, PDBj:1e3g
PDBsum1e3g
PubMed10840043
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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