Structure of PDB 1e1m Chain A

Receptor sequence
>1e1mA (length=455) Species: 9913 (Bos taurus) [Search protein sequence]
TPQICVVGSGPAGFYTAQHLLKHHSRAHVDIYEKQLVPFGLVRFGVAPDH
PEVKNVINTFTQTARSDRCAFYGNVEVGRDVTVQELQDAYHAVVLSYGAE
DHQALDIPGEELPGVFSARAFVGWYNGLPENRELAPDLSCDTAVILGQGN
VALDVARILLTPPDHLEKTDITEAALGALRQSRVKTVWIVGRRGPLQVAF
TIKELREMIQLPGTRPMLDPADFLGLQDRIKEAARPRKRLMELLLRTATE
KPGVEEAARRASASRAWGLRFFRSPQQVLPSPDGRRAAGIRLAVTRLEGI
GEATRAVPTGDVEDLPCGLVLSSIGYKSRPIDPSVPFDPKLGVVPNMEGR
VVDVPGLYCSGWVKRGPTGVITTTMTDSFLTGQILLQDLKAGHLPSGPRP
GSAFIKALLDSRGVWPVSFSDWEKLDAEEVSRGQASGKPREKLLDPQEML
RLLGH
3D structure
PDB1e1m Crystal Structures of Adrenodoxin Reductase in Complex with Nadp+ and Nadph Suggesting a Mechanism for the Electron Transfer of an Enzyme Family
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H55 D159 I376 T377
Catalytic site (residue number reindexed from 1) H50 D154 I371 T372
Enzyme Commision number 1.18.1.6: adrenodoxin-NADP(+) reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G13 G15 P16 A17 E38 K39 G45 L46 G50 V58 V82 Y102 G103 V156 W367 V375 I376 G8 G10 P11 A12 E33 K34 G40 L41 G45 V53 V77 Y97 G98 V151 W362 V370 I371
BS02 NAP A N155 V156 R197 R198 E209 P280 I329 Y331 T373 V375 N150 V151 R192 R193 E204 P275 I324 Y326 T368 V370
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015039 NADPH-adrenodoxin reductase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0022900 electron transport chain
GO:0070995 NADPH oxidation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Cellular Component
External links
PDB RCSB:1e1m, PDBe:1e1m, PDBj:1e1m
PDBsum1e1m
PubMed10998235
UniProtP08165|ADRO_BOVIN NADPH:adrenodoxin oxidoreductase, mitochondrial (Gene Name=FDXR)

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