Structure of PDB 1e08 Chain A

Receptor sequence

>1e08A (length=371) Species: 876 (Desulfovibrio desulfuricans)

FVQIDEAKCIGCDTCSQYCPTAAIFGEMGEPHSIPHIEACINCGQCLTHC
PENAIYEAQSWVPEVEKKLKDGKVKCIAMPAPAVRYALGDAFGMPVGSVT
TGKMLAALQKLGFAHCWDTEFTADVTIWEEGSEFVERLTKKSDMPLPQFT
SCCPGWQKYAETYYPELLPHFSTCKSPIGMNGALAKTYGAERMKYDPKQV
YTVSIMPCIAKKYEGLRPELKSSGMRDIDATLTTRELAYMIKKAGIDFAK
LPDGKRDSLMGESTGGATIFGVTGGVMEAALRFAYEAVTGKKPDSWDFKA
VRGLDGIKEATVNVGGTDVKVAVVHGAKRFKQVCDDVKAGKSPYHFIEYM
ACPGGCVCGGGQPVMPGVLEA

3D structure

• PDB: 1e08 Structural Model of the Fe-Hydrogenase/Cytochrome C553 Complex Combining Transverse Relaxation-Optimized Spectroscopy Experiments and Soft Docking Calculations.
• Chain: A
• Resolution: N/A

Enzymatic activity

• Catalytic site (original residue number in PDB): E156 E159 C178 S198 K237 E240 E245 C382
• Catalytic site (residue number reindexed from 1): E130 E133 C152 S172 K211 E214 E219 C356
• Enzyme Commision number: 1.12.7.2: ferredoxin hydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	I30 K34 C35 I36 G37 C38 D39 C41 H58 H75 C76 I81	I4 K8 C9 I10 G11 C12 D13 C15 H32 H49 C50 I55
BS02	SF4	A	V28 Y44 C45 I50 C66 N68 C69 G70 C72	V2 Y18 C19 I24 C40 N42 C43 G44 C46
BS03	SF4	A	C69 C179 C234 M376 C378 C382	C43 C153 C208 M350 C352 C356
BS04	PDT	A	A107 P108 A109 V110 F296 G297	A81 P82 A83 V84 F270 G271
BS05	FE2	A	P108 A293 F296	P82 A267 F270

External links

• PDB: RCSB:1e08, PDBe:1e08, PDBj:1e08
• PDBsum: 1e08
• PubMed: 10748163
• UniProt: P07598|PHFL_NITV2 Periplasmic [Fe] hydrogenase large subunit (Gene Name=hydA)