Structure of PDB 1dy9 Chain A

Receptor sequence
>1dy9A (length=175) Species: 31645 (Hepatitis C virus (isolate Taiwan)) [Search protein sequence]
APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESM
3D structure
PDB1dy9 Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64
BS02 2ZF A H57 K136 G137 S139 A156 A157 C159 H57 K136 G137 S139 A156 A157 C159
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:1dy9, PDBe:1dy9, PDBj:1dy9
PDBsum1dy9
PubMed10702283
UniProtP26662|POLG_HCVJA Genome polyprotein

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