Structure of PDB 1dxp Chain A

Receptor sequence
>1dxpA (length=175) Species: 31645 (Hepatitis C virus (isolate Taiwan)) [Search protein sequence]
APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESM
3D structure
PDB1dxp Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I3 T4 A5 Y6 S7 Q8 T10 R11 T19 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65 R109 I3 T4 A5 Y6 S7 Q8 T10 R11 T19 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65 R109
BS02 ZN A C97 C99 C145 C97 C99 C145
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1dxp, PDBe:1dxp, PDBj:1dxp
PDBsum1dxp
PubMed10702283
UniProtP26662|POLG_HCVJA Genome polyprotein

[Back to BioLiP]