Structure of PDB 1dwq Chain A

Receptor sequence
>1dwqA (length=262) Species: 3983 (Manihot esculenta) [Search protein sequence]
PISKMVTAHFVLIHTICHGAWIWHKLKPALERAGHKVTALDMAASGIDPR
QIEQINSFDEYSEPLLTFLEKLPQGEKVIIVGESCAGLNIAIAADRYVDK
IAAGVFHNSLLPDTVHSPSYTVEKLLESFPDWRDTEYFTFTNITGETITT
MKLGFVLLRENLFTKCTDGEYELAKMVMRKGSLFQNVLAQRPKFTEKGYG
SIKKVYIWTDQDKIFLPDFQRWQIANYKPDKVYQVQGGDHKLQLTKTEEV
AHILQEVADAYA
3D structure
PDB1dwq Structure of Hydroxynitrile Lyase from Manihot Esculenta in Complex with Substrates Acetone and Chloroacetone: Implications for the Mechanism of Cyanogenesis
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T11 S80 C81 D208 H236 K237
Catalytic site (residue number reindexed from 1) T15 S84 C85 D212 H240 K241
Enzyme Commision number 4.1.2.47: (S)-hydroxynitrile lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATO A S80 X81 W128 I210 H236 S84 X85 W132 I214 H240
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0047606 (S)-hydroxynitrile lyase activity
GO:0052891 aliphatic (S)-hydroxynitrile lyase activity
GO:0052892 aromatic (S)-hydroxynitrile lyase activity

View graph for
Molecular Function
External links
PDB RCSB:1dwq, PDBe:1dwq, PDBj:1dwq
PDBsum1dwq
PubMed11173464
UniProtP52705|HNL_MANES (S)-hydroxynitrile lyase (Gene Name=HNL)

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