Structure of PDB 1dvx Chain A

Receptor sequence

>1dvxA (length=115) Species: 9606 (Homo sapiens)

CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEQFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTN

3D structure

• PDB: 1dvx Rational design of potent human transthyretin amyloid disease inhibitors.
• Chain: A
• Resolution: 2.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DIF	A	L17 A108 L110 S117 T118 T119	L8 A99 L101 S108 T109 T110	BindingDB: Kd=1000nM,IC50=140000nM

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:1dvx, PDBe:1dvx, PDBj:1dvx
• PDBsum: 1dvx
• PubMed: 10742177
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)