Structure of PDB 1drt Chain A

Receptor sequence
>1drtA (length=315) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
TSVDCTAYGPELRALAARLPRTPRADLYAFLDAAHTAAASLPGALATALD
TFNAEGSEDGHLLLRGLPVEADADLPTTPSSTPAPEDRSLLTMEAMLGLV
GRRLGLHTGYRELRSGTVYHDVYPSPGAHHLSSETSETLLEFHTEMAYHR
LQPNYVMLACSRADHERTAATLVASVRKALPLLDERTRARLLDRRMPCCV
DVAFRIAQVKPLYGDADDPFLGYDRELLAPEDPADKEAVAALSKALDEVT
EAVYLEPGDLLIVDNFRTTHARTPFSPRWDGKDRWLHRVYIRTDRNGQLS
GGERAGDVVAFTPRG
3D structure
PDB1drt Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.21: clavaminate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCV A L114 L132 S134 H144 E146 M147 D202 R297 Y299 L113 L131 S133 H143 E145 M146 D201 R288 Y290
BS02 FE2 A H144 E146 H279 H143 E145 H270
BS03 AKG A L141 H144 E146 T172 H279 R281 R293 L295 R297 L140 H143 E145 T171 H270 R272 R284 L286 R288
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0033758 clavaminate synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0033050 clavulanic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1drt, PDBe:1drt, PDBj:1drt
PDBsum1drt
PubMed10655615
UniProtQ05581|CAS1_STRCL Clavaminate synthase 1 (Gene Name=cs1)

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