Structure of PDB 1dpg Chain A

Receptor sequence

>1dpgA (length=485) Species: 1245 (Leuconostoc mesenteroides)

VSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALN
DDEFKQLVRDCIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIE
EAADKFDIDGNRIFYMSVAPRFFGTIAKYLKSEGLLADTGYNRLMIEKPF
GTSYDTAAELQNDLENAFDDNQLFRIDHYLGKEMVQNIAALRFGNPIFDA
AWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQNHTMQIVGWLAM
EKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKPY
LEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIV
FKAGTFNFGSEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLG
WTVSDEDKKNTPEPYERMIHDTMNGDGSNFADWNGVSIAWKFVDAISAVY
TADKAPLETYKSGSMGPEASDKLLAANGDAWVFKG

3D structure

• PDB: 1dpg The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D177 H178 H240
• Catalytic site (residue number reindexed from 1): D177 H178 H240
• Enzyme Commision number: 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)(+)].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PO4	A	E147 K148 D177 H178	E147 K148 D177 H178
BS02	PO4	A	H178 Y179 K182	H178 Y179 K182

Gene Ontology

Molecular Function

• GO:0004345 glucose-6-phosphate dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050661 NADP binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006098 pentose-phosphate shunt
• GO:0009051 pentose-phosphate shunt, oxidative branch

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1dpg, PDBe:1dpg, PDBj:1dpg
• PDBsum: 1dpg
• PubMed: 7881907
• UniProt: P11411|G6PD_LEUME Glucose-6-phosphate 1-dehydrogenase (Gene Name=zwf)