Structure of PDB 1doj Chain A

Receptor sequence
>1dojA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDIVEGSDAEIGMSPWQV
MLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKH
SRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIH
PVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLP
IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFN
NRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
3D structure
PDB1doj Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H77 D133 E236 G237 D238 S239 G240
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F34 Q38 L65 R67 R73 T74 R75 Y76 K81 I82 M84 F53 Q58 L94 R96 R102 T103 R104 Y105 K111 I112 M114
BS02 1Z0 A H57 Y60A W60D K60F L99 D189 A190 E192 G193 S195 S214 W215 G216 H77 Y81 W84 K86 L130 D233 A234 E236 G237 S239 S260 W261 G262 PDBbind-CN: -logKd/Ki=8.96,Ki=1.1nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1doj, PDBe:1doj, PDBj:1doj
PDBsum1doj
PubMed11053836
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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