Structure of PDB 1doh Chain A

Receptor sequence
>1dohA (length=273) Species: 148305 (Pyricularia grisea) [Search protein sequence]
SKYDAIPGPLGPQSASLEGKVALVTGAGRGIGREMAMELGRRGCKVIVNY
ANSTESAEEVVAAIKKNGSDAACVKANVGVVEDIVRMFEEAVKIFGKLDI
VCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVAREAYKHLEIGGRLI
LMGSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKITVNVVAPGG
IKTDMYHAVCREYIPNGENLSNEEVDEYAAVQWSPLRRVGLPIDIARVVC
FLASNDGGWVTGKVIGIDGGACM
3D structure
PDB1doh Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G40 S164 H175 Y178 K182 Y223
Catalytic site (residue number reindexed from 1) G30 S154 H165 Y168 K172 Y213
Enzyme Commision number 1.1.1.252: tetrahydroxynaphthalene reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G36 R39 G40 I41 A61 N62 S63 N87 V88 N114 S115 G116 M162 Y178 K182 P208 G210 I211 T213 M215 G26 R29 G30 I31 A51 N52 S53 N77 V78 N104 S105 G106 M152 Y168 K172 P198 G200 I201 T203 M205
BS02 NID A Y178 G210 Y216 C220 Y223 Y168 G200 Y206 C210 Y213 MOAD: Ki=2.4nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047039 tetrahydroxynaphthalene reductase activity
Biological Process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Cellular Component
External links
PDB RCSB:1doh, PDBe:1doh, PDBj:1doh
PDBsum1doh
PubMed11342131
UniProtQ12634|T4HR_PYRO7 Tetrahydroxynaphthalene reductase (Gene Name=MGG_02252)

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