Structure of PDB 1dk4 Chain A

Receptor sequence
>1dk4A (length=252) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MKWDEIGKNIAKEIEKEILPYFGRKDKSYVVGTSPSGDETEIFDKISEDI
ALKYLKSLNVNIVSEELGVIDNSSEWTVVIDPIDGSFNFINGIPFFAFCF
GVFKNNEPYYGLTYEFLTKSFYEAYKGKGAYLNGRKIKVKDFNPNNIVIS
YYPSKKIDLEKLRNKVKRVRIFGAFGLEMCYVAKGTLDAVFDVRPKVRAV
DIASSYIICKEAGALITDENGDELKFDLNATDRLNIIVANSKEMLDIILD
LL
3D structure
PDB1dk4 MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E65 D81 I83 D84 D201
Catalytic site (residue number reindexed from 1) E65 D81 I83 D84 D201
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
3.1.3.25: inositol-phosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D81 D84 D201 D81 D84 D201
BS02 ZN A E65 D81 I83 E65 D81 I83
Gene Ontology
Molecular Function
GO:0008934 inositol monophosphate 1-phosphatase activity
GO:0016787 hydrolase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0046872 metal ion binding
GO:0052832 inositol monophosphate 3-phosphatase activity
GO:0052833 inositol monophosphate 4-phosphatase activity
GO:0052834 inositol monophosphate phosphatase activity
Biological Process
GO:0006020 inositol metabolic process
GO:0007165 signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1dk4, PDBe:1dk4, PDBj:1dk4
PDBsum1dk4
PubMed11062561
UniProtQ57573|BSUHB_METJA Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (Gene Name=suhB)

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