Structure of PDB 1djx Chain A

Receptor sequence
>1djxA (length=513) Species: 10116 (Rattus norvegicus) [Search protein sequence]
EIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPA
LALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMD
QPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPN
QEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQR
VMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLKLVPELS
DMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHN
VSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCF
QDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPK
VNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVT
VPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQH
PSATLFVKISIQD
3D structure
PDB1djx Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H311 N312 E341 D343 H356 E390
Catalytic site (residue number reindexed from 1) H112 N113 E142 D144 H157 E191
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N312 E341 D343 E390 N113 E142 D144 E191
BS02 CA A I651 D653 N677 I408 D410 N434
BS03 I3P A H311 N312 E341 H356 E390 K438 S522 R549 Y551 H112 N113 E142 H157 E191 K239 S279 R306 Y308 MOAD: Kd=1.7uM
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1djx, PDBe:1djx, PDBj:1djx
PDBsum1djx
PubMed9048554
UniProtP10688|PLCD1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Gene Name=Plcd1)

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