Structure of PDB 1dew Chain A

Receptor sequence
>1dewA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
GPALYEDPPDHKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPD
ILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPL
KVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDE
AFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHS
LLPALCDSKIRSKALGSDHCPITLYLAL
3D structure
PDB1dew DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D70 E96 N212 D283 D308
Catalytic site (residue number reindexed from 1) D30 E56 N172 D243 D268
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E96 Y128 Y171 N174 R177 D210 N212 N222 N226 F266 T268 M271 V278 H309 E56 Y88 Y131 N134 R137 D170 N172 N182 N186 F226 T228 M231 V238 H269
BS02 dna A G71 R73 A74 K78 E126 G127 K224 Y269 M270 M271 G31 R33 A34 K38 E86 G87 K184 Y229 M230 M231
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1dew, PDBe:1dew, PDBj:1dew
PDBsum1dew
PubMed10667800
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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