Structure of PDB 1d8i Chain A

Receptor sequence
>1d8iA (length=288) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
HMYRNVPIWAQKWKPTIKALQSINVKDLKIDPSFLNIIPDDDLTKSVQDW
VYATIYSIAPELRSFIELEMKFGVIIDAKGPDRVNPPVSSQCVFTELDAH
LTPNIDASLFKELSKYIRGISEVTENTGKFSIIESQTRDSVYRVGPRFLR
MSTDIKTGRVGQFIEKRHVAQLLLYSPKDSYDVKISLNLELPVPDNDPPE
KYKSQSPISERTKDRVSYIHNDSCTRIDITKVENHSETTHEVELEINTPA
LLNAFDNITNDSKEYASLIRTFLNNGTIIRRKLSSLSY
3D structure
PDB1d8i Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E305 E307 R393 K409 K456 E496
Catalytic site (residue number reindexed from 1) E67 E69 R150 K166 K213 E245
Enzyme Commision number 3.6.1.74: mRNA 5'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A K456 R458 K213 R215
BS02 SO4 A Q249 K250 W251 Y294 Q11 K12 W13 Y56
Gene Ontology
Molecular Function
GO:0004651 polynucleotide 5'-phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:1d8i, PDBe:1d8i, PDBj:1d8i
PDBsum1d8i
PubMed10589681
UniProtO13297|CET1_YEAST mRNA-capping enzyme subunit beta (Gene Name=CET1)

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