Structure of PDB 1d6w Chain A

Receptor sequence
>1d6wA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
ADCGLRPLFEKKSLEDKTERELLESYIDIVEGSDAEIGMSPWQVMLFRKS
PQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYE
RNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPD
RETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRI
RITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGE
GCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1d6w Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H71 D127 E223 G224 D225 S226 G227
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F34 L65 R73 T74 R75 Y76 F47 L88 R96 T97 R98 Y99
BS02 00R A H57 Y60A W60D N98 L99 I174 D189 S195 W215 G216 G219 G226 H71 Y75 W78 N123 L124 I200 D220 S226 W248 G249 G251 G259 MOAD: Ki=1100nM
PDBbind-CN: -logKd/Ki=5.96,Ki=1100nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1d6w, PDBe:1d6w, PDBj:1d6w
PDBsum1d6w
PubMed10713516
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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