Structure of PDB 1d3c Chain A

Receptor sequence

>1d3cA (length=686) Species: 1397 (Niallia circulans) [Search protein sequence]

APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGTCTNLRLYC
GGDWQGIINKINDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGY
WARDFKKTNPAYGTIADFQNLIAAAHAKNIKVIIDFAPNHTSPASSDQPS
FAENGRLYDNGTLLGGYTNDTQNLFHHNGGTDFSTTENGIYKNLYDLADL
NHNNSTVDVYLKDAIKMWLDLGIDGIRMNAVKHMPFGWQKSFMAAVNNYK
PVFTFGQWFLGVNEVSPENHKFANESGMSLLDFRFAQKVRQVFRDNTDNM
YGLKAMLEGSAADYAQVDDQVTFIDNHDMERFHASNANRRKLEQALAFTL
TSRGVPAIYYGTEQYMSGGTDPDNRARIPSFSTSTTAYQVIQKLAPLRKC
NPAIAYGSTQERWINNDVLIYERKFGSNVAVVAVNRNLNAPASISGLVTS
LPQGSYNDVLGGLLNGNTLSVGSGGAASNFTLAAGGTAVWQYTAATATPT
IGHVGPMMAKPGVTITIDGRGFGSSKGTVYFGTTAVSGADITSWEDTQIK
VKIPAVAGGNYNIKVANAAGTASNVYDNFEVLSGDQVSVRFVVNNATTAL
GQNVYLTGSVSELGNWDPAKAIGPMYNQVVYQYPNWYYDVSVPAGKTIEF
KFLKKQGSTVTWEGGSNHTFTAPSSGTATINVNWQP

3D structure

PDB

1d3c The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8-A resolution.

Chain

Resolution

1.78 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D135 R227 N229 Q257 H327 D328
Catalytic site (residue number reindexed from 1)	D135 R227 N229 Q257 H327 D328
Enzyme Commision number	2.4.1.19: cyclomaltodextrin glucanotransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	W413 I414 G446	W413 I414 G446
BS02	GLC	A	E411 R412 G446	E411 R412 G446
BS03	GLC	A	F183 K232 F259	F183 K232 F259
BS04	GLC	A	Y195 A230 K232 H233 Q257	Y195 A230 K232 H233 Q257
BS05	GLC	A	Y100 H140 N229 Q257 H327 D328	Y100 H140 N229 Q257 H327 D328
BS06	GLC	A	H98 Y100 W101 D371 R375	H98 Y100 W101 D371 R375
BS07	GLC	A	R47 D371	R47 D371
BS08	GLC	A	K651 W662	K651 W662
BS09	GLC	A	W616 W662 N667	W616 W662 N667
BS10	GLC	A	A599 G601 Q602 N603 N627	A599 G601 Q602 N603 N627
BS11	GLC	A	T598 A599 Y633	T598 A599 Y633
BS12	CA	A	D27 N29 N32 N33 G51 D53	D27 N29 N32 N33 G51 D53
BS13	CA	A	N139 I190 D199 H233	N139 I190 D199 H233
BS14	CA	A	A315 D577	A315 D577

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004556	alpha-amylase activity
GO:0016757	glycosyltransferase activity
GO:0030246	carbohydrate binding
GO:0043169	cation binding
GO:0043895	cyclomaltodextrin glucanotransferase activity
GO:0046872	metal ion binding
GO:2001070	starch binding

	Biological Process
GO:0005975	carbohydrate metabolic process

	Cellular Component
GO:0005576	extracellular region

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1d3c, PDBe:1d3c, PDBj:1d3c
PDBsum	1d3c
PubMed	10574960
UniProt	P43379\|CDGT2_NIACI Cyclomaltodextrin glucanotransferase (Gene Name=cgt)

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