Structure of PDB 1d1s Chain A

Receptor sequence
>1d1sA (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDD
HVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCREC
NACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTV
VDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLG
GVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPIS
EVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKML
TYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLP
FKKISEGFELLNSGQSIRTVLTF
3D structure
PDB1d1s Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369
Catalytic site (residue number reindexed from 1) C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C173 T177 R368
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
1.1.1.105: all-trans-retinol dehydrogenase (NAD(+)).
1.1.1.66: omega-hydroxydecanoate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C97 C100 C103 C111 C97 C100 C103 C111
BS02 ZN A C46 H67 C174 C46 H67 C173
BS03 ZN A E357 E360 E356 E359
BS04 NAD A R47 T48 H51 C174 T178 G201 G202 V203 D223 L224 K228 V268 I269 H271 V292 G293 V294 F319 R47 T48 H51 C173 T177 G200 G201 V202 D222 L223 K227 V267 I268 H270 V291 G292 V293 F318
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004031 aldehyde oxidase activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019841 retinol binding
GO:0035276 ethanol binding
GO:0046872 metal ion binding
GO:0048019 receptor antagonist activity
GO:0050153 omega-hydroxydecanoate dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006629 lipid metabolic process
GO:0009617 response to bacterium
GO:0010430 fatty acid omega-oxidation
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0045471 response to ethanol
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:1d1s, PDBe:1d1s, PDBj:1d1s
PDBsum1d1s
PubMed10631979
UniProtP40394|ADH7_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH7 (Gene Name=ADH7)

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