Structure of PDB 1cy5 Chain A

Receptor sequence
>1cy5A (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQ
QRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIP
3D structure
PDB1cy5 Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E17 I91 P92 E17 I91 P92
BS02 ZN A D27 E40 D27 E40
BS03 ZN A H28 D32 H28 D32
BS04 ZN A H28 E78 H28 E78
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0070513 death domain binding
Biological Process
GO:0042981 regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1cy5, PDBe:1cy5, PDBj:1cy5
PDBsum1cy5
PubMed10543941
UniProtO14727|APAF_HUMAN Apoptotic protease-activating factor 1 (Gene Name=APAF1)

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