Structure of PDB 1cwt Chain A

Receptor sequence
>1cwtA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVI
VDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHC
EFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFC
EPQDYRPMNHEAFKDELKTFRLKTRSW
3D structure
PDB1cwt Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A C473 E474 F475 S477 E478 R479 W550 C100 E101 F102 S104 E105 R106 W177
BS02 SO4 A R488 R492 R115 R119
BS03 CL A E446 R548 E73 R175
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1cwt, PDBe:1cwt, PDBj:1cwt
PDBsum1cwt
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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