Structure of PDB 1cws Chain A

Receptor sequence
>1cwsA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
SDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFV
IVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFH
CEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNF
CEPQDYRPMNHEAFKDELKTFRLKTRSW
3D structure
PDB1cws Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO4 A C473 E474 F475 S476 S477 E478 R479 W550 C101 E102 F103 S104 S105 E106 R107 W178 BindingDB: IC50=30000nM
BS02 CL A L445 E446 T547 R548 L73 E74 T175 R176
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1cws, PDBe:1cws, PDBj:1cws
PDBsum1cws
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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