Structure of PDB 1cwe Chain A

Receptor sequence
>1cweA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
GSWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ
GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSR
3D structure
PDB1cwe The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R12 R32 S42 H58 Y59 I71 S72 R74 R10 R30 S40 H56 Y57 I69 S70 R72
External links
PDB RCSB:1cwe, PDBe:1cwe, PDBj:1cwe
PDBsum1cwe
PubMed7532720
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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