Structure of PDB 1cvr Chain A

Receptor sequence
>1cvrA (length=432) Species: 837 (Porphyromonas gingivalis) [Search protein sequence]
YTPVEEKENGRMIVIVAKKYEGDIKDFVDWKNQRGLRTEVKVAEDIASPV
TANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIV
GNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIAS
AEGGPSADNGESDIQHENVIANLLTQYGYTKIIKCYDPGVTPKNIIDAFN
GGISLVNYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFL
FSMPCFAEALMRAQKDGKPTGTVAIIASTIDQYWAPPMRGQDEMNEILCE
KHPNNIKRTFGGVTMNGMFAMVEKYKKDGENMLDTWTVFGDPSLLVRTLV
PTEMQVTAPANISASAQTFEVACDYNGAIATLSDDGDMVGTAIVKDGKAI
IKLNESIADETNLTLTVVGYNKVTVIKDVKVE
3D structure
PDB1cvr Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E152 H211 G212 C244
Catalytic site (residue number reindexed from 1) E152 H211 G212 C244
Enzyme Commision number 3.4.22.37: gingipain R.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H37 A D163 G210 H211 V242 C244 Q282 Y283 W284 M288 D163 G210 H211 V242 C244 Q282 Y283 W284 M288
BS02 CA A E161 H166 D292 E161 H166 D292
BS03 CA A D78 F249 E258 D78 F249 E258
BS04 CA A V100 D103 Y105 E107 V100 D103 Y105 E107
BS05 CA A E293 E296 H302 E293 E296 H302
BS06 ZN A E152 H211 E152 H211
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1cvr, PDBe:1cvr, PDBj:1cvr
PDBsum1cvr
PubMed10523290
UniProtP95493|CPG2_PORGI Gingipain R2 (Gene Name=rgpB)

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