Structure of PDB 1ctt Chain A

Receptor sequence
>1cttA (length=294) Species: 562 (Escherichia coli) [Search protein sequence]
MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDED
ALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQT
VHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLP
GREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAAN
RSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLK
GYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
3D structure
PDB1ctt Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H102 E104 C129 C132
Catalytic site (residue number reindexed from 1) H102 E104 C129 C132
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H102 C129 C132 H102 C129 C132
BS02 DHZ A F71 N89 E91 H102 E104 F71 N89 E91 H102 E104 MOAD: Ki=30uM
PDBbind-CN: -logKd/Ki=4.52,Ki=30uM
Gene Ontology
Molecular Function
GO:0001884 pyrimidine nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006217 deoxycytidine catabolic process
GO:0009972 cytidine deamination
GO:0015949 nucleobase-containing small molecule interconversion
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ctt, PDBe:1ctt, PDBj:1ctt
PDBsum1ctt
PubMed7718553
UniProtP0ABF6|CDD_ECOLI Cytidine deaminase (Gene Name=cdd)

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