Structure of PDB 1cqp Chain A

Receptor sequence
>1cqpA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVI
3D structure
PDB1cqp Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S139 S141 D239 S12 S14 D112
BS02 803 A L132 I235 Y257 L298 L302 L5 I108 Y130 L171 L175 PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
BindingDB: Kd=12900nM,IC50=2400nM
BS03 803 A V308 I309 V181 I182 PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
BindingDB: Kd=12900nM,IC50=2400nM
External links
PDB RCSB:1cqp, PDBe:1cqp, PDBj:1cqp
PDBsum1cqp
PubMed10493852
UniProtP20701|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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