Structure of PDB 1cm1 Chain A

Receptor sequence

>1cm1A (length=143) Species: 9913 (Bos taurus) [Search protein sequence]

LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN
EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAA
ELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

3D structure

PDB

1cm1 Motions of calmodulin characterized using both Bragg and diffuse X-ray scattering.

Chain

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V35
Catalytic site (residue number reindexed from 1)	V32
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	E7 E11 F12 E14 A15 L18 F19 M36 E84 F92 E120 M124 F141 M144 M145	E4 E8 F9 E11 A12 L15 F16 M33 E81 F89 E117 M121 F138 M141 M142
BS02	CA	A	D20 D22 D24 T26 E31	D17 D19 D21 T23 E28
BS03	CA	A	D56 D58 N60 T62 E67	D53 D55 N57 T59 E64
BS04	CA	A	D93 D95 N97 Y99 E104	D90 D92 N94 Y96 E101
BS05	CA	A	D129 D131 D133 Q135 E140	D126 D128 D130 Q132 E137
BS06	CA	A	Y99 D133 Q135	Y96 D130 Q132

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

	Biological Process
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity

External links

PDB	RCSB:1cm1, PDBe:1cm1, PDBj:1cm1
PDBsum	1cm1
PubMed	9438860
UniProt	P62157\|CALM_BOVIN Calmodulin (Gene Name=CALM)