Structure of PDB 1cm0 Chain A

Receptor sequence
>1cm0A (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
KVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDP
KHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMN
HLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYE
GATLMGCELNPR
3D structure
PDB1cm0 Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F563 F568 E570 I571 V572 C574 L606 I637 Y640
Catalytic site (residue number reindexed from 1) F72 F77 E79 I80 V81 C83 L115 I146 Y149
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A Q525 C574 A575 V576 Q581 V582 G584 G586 T587 Y612 G615 Y616 F617 Q34 C83 A84 V85 Q90 V91 G93 G95 T96 Y121 G124 Y125 F126 BindingDB: IC50=41910nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:1cm0, PDBe:1cm0, PDBj:1cm0
PDBsum1cm0
PubMed10393169
UniProtQ92831|KAT2B_HUMAN Histone acetyltransferase KAT2B (Gene Name=KAT2B)

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