Structure of PDB 1clu Chain A

Receptor sequence
>1cluA (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAPGVGKSALTIQLIQNHFVDEDSYRKQVVIDGETCLLDIL
DTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDS
DDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAF
YTLVREIRQH
3D structure
PDB1clu Guanosine triphosphatase stimulation of oncogenic Ras mutants.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DBG A P12 G13 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 S145 A146 P12 G13 G15 K16 S17 A18 F28 V29 D30 N110 K111 D113 S139 A140 MOAD: Kd=5.4nM
PDBbind-CN: -logKd/Ki=8.27,Kd=5.4nM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1clu, PDBe:1clu, PDBj:1clu
PDBsum1clu
PubMed10359839
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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