Structure of PDB 1cjw Chain A

Receptor sequence
>1cjwA (length=166) Species: 9940 (Ovis aries) [Search protein sequence]
HTLPANEFRCLTPEDAAGVFEIEREAFISVSGNCPLNLDEVQHFLTLCPE
LSLGWFVEGRLVAFIIGSLWDEERLTQESLALHRPRGHSAHLHALAVHRS
FRQQGKGSVLLWRYLHHVGAQPAVRRAVLMCEDALVPFYQRFGFHPAGPC
AIVVGSLTFTEMHCSL
3D structure
PDB1cjw The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S97 L111 H122 L124 Y168
Catalytic site (residue number reindexed from 1) S68 L82 H93 L95 Y139
Enzyme Commision number 2.3.1.87: aralkylamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COT A F56 C63 P64 A123 L124 A125 V126 R131 Q132 G134 G136 S137 M159 A163 L164 F167 Y168 R170 L186 F188 F27 C34 P35 A94 L95 A96 V97 R102 Q103 G105 G107 S108 M130 A134 L135 F138 Y139 R141 L157 F159
Gene Ontology
Molecular Function
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:1cjw, PDBe:1cjw, PDBj:1cjw
PDBsum1cjw
PubMed10319816
UniProtQ29495|SNAT_SHEEP Serotonin N-acetyltransferase (Gene Name=AANAT)

[Back to BioLiP]