Structure of PDB 1cjt Chain A

Receptor sequence
>1cjtA (length=189) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL
AAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREM
TGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRI
HITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL
3D structure
PDB1cjt Two-metal-Ion catalysis in adenylyl cyclase.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D396 I397 D440 H516
Catalytic site (residue number reindexed from 1) D20 I21 D64 H140
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D396 D440 D20 D64
BS02 MN A D396 I397 D440 D20 I21 D64
BS03 FOK A V506 W507 S508 V511 T512 N515 V130 W131 S132 V135 T136 N139
BS04 DAD A D396 I397 G399 F400 T401 L438 G439 D440 R484 D20 I21 G23 F24 T25 L62 G63 D64 R108
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1cjt, PDBe:1cjt, PDBj:1cjt
PDBsum1cjt
PubMed10427002
UniProtP30803|ADCY5_CANLF Adenylate cyclase type 5 (Gene Name=ADCY5)

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