Structure of PDB 1cdo Chain A

Receptor sequence

>1cdoA (length=374) Species: 8053 (Gadus morhua callarias)

ATVGKVIKCKAAVAWEANKPLVIEEIEVDVPHANEIRIKIIATGVCHTDL
YHLFEGKHKDGFPVVLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGE
CRFCQSPKTNQCVKGWANESPDVMSPKETRFTCKGRKVLQFLGTSTFSQY
TVVNQIAVAKIDPSAPLDTVCLLGCGVSTGFGAAVNTAKVEPGSTCAVFG
LGAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFVNPNDHSEP
ISQVLSKMTNGGVDFSLECVGNVGVMRNALESCLKGWGVSVLVGWTDLHD
VATRPIQLIAGRTWKGSMFGGFKGKDGVPKMVKAYLDKKVKLDEFITHRM
PLESVNDAIDLMKHGKCIRTVLSL

3D structure

• PDB: 1cdo Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments.
• Chain: A
• Resolution: 2.05 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C46 H47 T48 Y51 H68 E69 C98 C101 C104 C112 W116 C175 T179 R369
• Catalytic site (residue number reindexed from 1): C46 H47 T48 Y51 H68 E69 C98 C101 C104 C112 W116 C175 T179 R369
• Enzyme Commision number: 1.1.1.1: alcohol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C46 H68	C46 H68
BS02	ZN	A	C98 C104 C112	C98 C104 C112
BS03	NAD	A	C46 H47 T48 C175 T179 G202 V204 D224 L225 V270 G271 V293 W295	C46 H47 T48 C175 T179 G202 V204 D224 L225 V270 G271 V293 W295

Gene Ontology

Molecular Function

• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

Biological Process

• GO:0046294 formaldehyde catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1cdo, PDBe:1cdo, PDBj:1cdo
• PDBsum: 1cdo
• PubMed: 8845755
• UniProt: P26325|ADH1_GADMC Alcohol dehydrogenase 1