Structure of PDB 1ca9 Chain A

Receptor sequence
>1ca9A (length=191) Species: 9606 (Homo sapiens) [Search protein sequence]
QDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD
FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF
FVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPV
NDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
3D structure
PDB1ca9 Structural basis for self-association and receptor recognition of human TRAF2.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R393 Y395 D399 G400 F410 F447 R448 F456 A466 S467 G468 R83 Y85 D89 G90 F100 F137 R138 F146 A156 S157 G158
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1ca9, PDBe:1ca9, PDBj:1ca9
PDBsum1ca9
PubMed10206649
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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