Structure of PDB 1c9w Chain A

Receptor sequence
>1c9wA (length=315) Species: 10029 (Cricetulus griseus) [Search protein sequence]
STFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYN
EHEVGEAIQEKIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLK
LDYLDLYLIHWPQGLQPGKELFPKDDQGNVLTSKITFLDAWEVMEELVDE
GLVKALGVSNFNHFQIERILNKPGLKHKPVTNQVECHPYLTQEKLIEYCH
SKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAKHKKTSAQVLIR
FHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACLL
PETVNMEEYPYDAEY
3D structure
PDB1c9w Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D43 Y48 K77 H110
Catalytic site (residue number reindexed from 1) D43 Y48 K77 H110
Enzyme Commision number 1.1.1.21: aldose reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G18 T19 W20 Y48 H110 N160 Y209 S210 P211 L212 S214 N216 I260 K262 S263 V264 T265 R268 E271 N272 G18 T19 W20 Y48 H110 N160 Y209 S210 P211 L212 S214 N216 I260 K262 S263 V264 T265 R268 E271 N272
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:1c9w, PDBe:1c9w, PDBj:1c9w
PDBsum1c9w
PubMed10651037
UniProtO08782|ALD2_CRIGR Aldose reductase-related protein 2 (Gene Name=AKR1B8)

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