Structure of PDB 1c1r Chain A

Receptor sequence

>1c1rA (length=223) Species: 9913 (Bos taurus)

IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN

3D structure

• PDB: 1c1r Design of potent selective zinc-mediated serine protease inhibitors.
• Chain: A
• Resolution: 1.37 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 Q192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H40 D84 Q174 G175 D176 S177 G178
• Enzyme Commision number: 3.4.21.4: trypsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E70 N72 V75 V76 E80	E52 N54 V57 V58 E62
BS02	MG	A	Q30 S139 D194	Q15 S119 D176
BS03	ZN	A	H57 S195	H40 S177
BS04	BAI	A	D189 S190 V213 G219 C220	D171 S172 V191 G196 C197	MOAD: Ki=0.0235uM PDBbind-CN: -logKd/Ki=7.63,Ki=0.0235uM

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0097655 serpin family protein binding

Biological Process

• GO:0006508 proteolysis
• GO:0007586 digestion

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0097180 serine protease inhibitor complex

External links

• PDB: RCSB:1c1r, PDBe:1c1r, PDBj:1c1r
• PDBsum: 1c1r
• PubMed: 9468142
• UniProt: P00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)