Structure of PDB 1c0n Chain A

Receptor sequence
>1c0nA (length=404) Species: 562 (Escherichia coli) [Search protein sequence]
FSVDAVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYA
AVHAGAHTLSAQATEKMENVRKRASLFINARSAEELVFVRGTTEGINLVA
NSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTL
QLETLPTLFDAATRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGA
QAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGG
GSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNI
AEYEQNLMHYALSQLESVPDLTLYGPQARLGVIAFNLGAHHAYDVGSFLD
NYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRIH
RLLG
3D structure
PDB1c0n Structure of a NifS homologue: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H123 D200 A202 Q203 K226 R359 C364
Catalytic site (residue number reindexed from 1) H121 D198 A200 Q201 K224 R357 C362
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
3.13.1.-
4.4.1.16: selenocysteine lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A T94 T95 H123 D200 A202 Q203 S223 H225 K226 T92 T93 H121 D198 A200 Q201 S221 H223 K224
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008826 cysteine sulfinate desulfinase activity
GO:0009000 selenocysteine lyase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006534 cysteine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1c0n, PDBe:1c0n, PDBj:1c0n
PDBsum1c0n
PubMed10684605
UniProtP77444|SUFS_ECOLI Cysteine desulfurase (Gene Name=sufS)

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