Structure of PDB 1byg Chain A

Receptor sequence
>1bygA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDAQAFLAEAS
VMTQLRHSNLVQLLGVIVEEGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC
LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLLPVKW
TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG
YKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL
3D structure
PDB1byg Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D314 A316 R318 N319 D332 P349
Catalytic site (residue number reindexed from 1) D124 A126 R128 N129 D142 P147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I201 K203 V209 A220 T266 E267 Y268 M269 G272 R318 N319 L321 I15 K17 V23 A34 T76 E77 Y78 M79 G82 R128 N129 L131
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1byg, PDBe:1byg, PDBj:1byg
PDBsum1byg
PubMed9878439
UniProtP41240|CSK_HUMAN Tyrosine-protein kinase CSK (Gene Name=CSK)

[Back to BioLiP]