Structure of PDB 1by4 Chain A

Receptor sequence
>1by4A (length=79) Species: 9606 (Homo sapiens) [Search protein sequence]
TKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEER
3D structure
PDB1by4 Structural basis of RXR-DNA interactions.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K1145 H1146 K1160 R1209 K15 H16 K30 R79 PDBbind-CN: Kd=350nM
BS02 dna A E1153 R1161 N1185 Q1188 R1191 E23 R31 N55 Q58 R61 PDBbind-CN: Kd=350nM
BS03 ZN A C1135 C1138 C1155 C5 C8 C25
BS04 ZN A C1177 C1187 C1190 C47 C57 C60
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1by4, PDBe:1by4, PDBj:1by4
PDBsum1by4
PubMed10669605
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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