Structure of PDB 1bx4 Chain A

Receptor sequence
>1bx4A (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
VRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELV
KKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLE
KNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFIS
QFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPK
MNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFV
GGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
3D structure
PDB1bx4 Structure of human adenosine kinase at 1.5 A resolution.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R132 G297 A298 G299 D300
Catalytic site (residue number reindexed from 1) R129 G294 A295 G296 D297
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D130 N131 D127 N128
BS02 ADN A N14 L16 D18 G64 S65 N68 F170 N296 D300 N11 L13 D15 G61 S62 N65 F167 N293 D297
BS03 ADN A T265 G267 R268 Q289 I292 A327 I331 T262 G264 R265 Q286 I289 A324 I328
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004001 adenosine kinase activity
GO:0004136 deoxyadenosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006175 dATP biosynthetic process
GO:0006753 nucleoside phosphate metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0032263 GMP salvage
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044209 AMP salvage
GO:0106383 dAMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1bx4, PDBe:1bx4, PDBj:1bx4
PDBsum1bx4
PubMed9843365
UniProtP55263|ADK_HUMAN Adenosine kinase (Gene Name=ADK)

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