Structure of PDB 1bul Chain A

Receptor sequence
>1bulA (length=265) Species: 550 (Enterobacter cloacae) [Search protein sequence]
NTKGIDEIKNLETDFNGRIGVYALDTGSGKSFSYRANERFPLCSSFKGFL
AAAVLKGSQDNRLNLNQIVNYNTRSLEFHSPITTKYKDNGMSLGDMAAAA
LQYSDNGATNIILERYIGGPEGMTKFMRSIGDEDFRLDRWELDLNTAIPG
DERDTSTPAAVAKSLKTLALGNILSEHEKETYQTWLKGNTTGAARIRASV
PSDWVVGDKTGSCGAYGTANDYAVVWPKNRAPLIISVYTTKNEKEAKHED
KVIAEASRIAIDNLK
3D structure
PDB1bul Inhibition of the Nmc-A B-Lactamase by a Penicillanic Acid Derivative, and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme
ChainA
Resolution1.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 S237
Catalytic site (residue number reindexed from 1) S44 K47 S104 E141 K209 S212
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AP3 A S70 S130 N132 N170 T235 S237 S44 S104 N106 N145 T210 S212
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:1bul, PDBe:1bul, PDBj:1bul
PDBsum1bul
PubMed
UniProtP52663|BLAN_ENTCL Imipenem-hydrolyzing beta-lactamase (Gene Name=nmcA)

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