Structure of PDB 1bq6 Chain A

Receptor sequence

>1bq6A (length=388) Species: 3879 (Medicago sativa)

VSVSEIRKAQRAEGPATILAIGTANPANCVEQSTYPDFYFKITNSEHKTE
LKEKFQRMCDKSMIKRRYMYLTEEILKENPNVCEYMAPSLDARQDMVVVE
VPRLGKEAAVKAIKEWGQPKSKITHLIVCTTSGVDMPGADYQLTKLLGLR
PYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGP
SDTHLDSLVGQALFGDGAAALIVGSDPVPEIEKPIFEMVWTAQTIAPDSE
GAIDGHLREAGLTFHLLKDVPGIVSKNITKALVEAFEPLGISDYNSIFWI
AHPGGPAILDQVEQKLALKPEKMNATREVLSEYGNMSSACVLFILDEMRK
KSTQNGLKTTGEGLEWGVLFGFGPGLTIETVVLRSVAI

3D structure

• PDB: 1bq6 Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
• Chain: A
• Resolution: 1.56 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C164 F215 H303 N336
• Catalytic site (residue number reindexed from 1): C163 F214 H302 N335
• Enzyme Commision number: 2.3.1.74: chalcone synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	A	K55 R58 M59 K62 V210 I254 F265 L267 V271 P272 G305 G306 P307 A308	K54 R57 M58 K61 V209 I253 F264 L266 V270 P271 G304 G305 P306 A307

Gene Ontology

Molecular Function

• GO:0016210 naringenin-chalcone synthase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

Biological Process

• GO:0009058 biosynthetic process
• GO:0009715 chalcone biosynthetic process
• GO:0009813 flavonoid biosynthetic process
• GO:0030639 polyketide biosynthetic process

External links

• PDB: RCSB:1bq6, PDBe:1bq6, PDBj:1bq6
• PDBsum: 1bq6
• PubMed: 10426957
• UniProt: P30074|CHS2_MEDSA Chalcone synthase 2 (Gene Name=CHS2)