Structure of PDB 1bpm Chain A

Receptor sequence
>1bpmA (length=481) Species: 9913 (Bos taurus) [Search protein sequence]
TKGLVLGIYSKEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRT
FYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQIQDL
EIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSEDQEA
WQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIR
PKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGIT
FDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLC
ENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKV
IINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLF
EHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGV
MTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQ
3D structure
PDB1bpm Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K262 R336
Catalytic site (residue number reindexed from 1) K259 R333
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.5: prolyl aminopeptidase.
3.4.13.23: cysteinylglycine-S-conjugate dipeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D255 D332 E334 D252 D329 E331
BS02 ZN A D255 D273 E334 D252 D270 E331
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0008233 peptidase activity
GO:0016805 dipeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
GO:0097718 disordered domain specific binding
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1bpm, PDBe:1bpm, PDBj:1bpm
PDBsum1bpm
PubMed8506345
UniProtP00727|AMPL_BOVIN Cytosol aminopeptidase (Gene Name=LAP3)

[Back to BioLiP]