Structure of PDB 1bk6 Chain A

Receptor sequence

>1bk6A (length=422) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEF
MRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVE
VKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWT
LSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGP
QEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVI
NAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL
VKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLE
IADNRIIEVTLDALENIIKMGEADKEARGLNINENADFIEKAGGMEKIFN
CQQNENDKIYEKAYKIIETYFG

3D structure

PDB

1bk6 Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R117 P121 W153 N157 G161 T166 Q192 W195 N199 D203 W237 N241	R29 P33 W65 N69 G73 T78 Q104 W107 N111 D115 W149 N153
BS02	peptide	A	G329 W363 N367 E402 W405	G241 W275 N279 E314 W317

External links

PDB	RCSB:1bk6, PDBe:1bk6, PDBj:1bk6
PDBsum	1bk6
PubMed	9695948
UniProt	Q02821\|IMA1_YEAST Importin subunit alpha (Gene Name=SRP1)

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