Structure of PDB 1bk4 Chain A

Receptor sequence
>1bk4A (length=314) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
FDTDISTMTRFVMEEGRKAGGTGEMTQLLNSLCTAVKAISTAVRKAGIKL
DVLSNDLVMNMLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGS
SNIDCLVSIGTIFGIYRKKSTDEPSTKDALQPGRNLVAAGYALYGSATML
VLAGGSGVNSFMLDPAIGEFILVDKNVKIKKKGNIYSLNEGYAKDFDPAV
TEYIQKKKFPPDNSSPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPDG
KLRLLYECNPMAFIMEKAGGMATTGKEAILDIVPTDIHQRAPVILGSPDD
VQEFLEIYKKHAVK
3D structure
PDB1bk4 Structure of rabbit liver fructose 1,6-bisphosphatase at 2.3 A resolution.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D74 E97 E98 D118 L120 D121 E280
Catalytic site (residue number reindexed from 1) D51 E74 E75 D95 L97 D98 E257
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E97 D118 D121 E280 E74 D95 D98 E257
BS02 SO4 A N212 Y215 Y244 Y264 N189 Y192 Y221 Y241
BS03 SO4 A G26 T27 G28 E29 M30 K112 Y113 G21 T22 G23 E24 M25 K89 Y90
Gene Ontology
Molecular Function
GO:0016208 AMP binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0071286 cellular response to magnesium ion
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1bk4, PDBe:1bk4, PDBj:1bk4
PDBsum1bk4
PubMed10089399
UniProtP00637|F16P1_RABIT Fructose-1,6-bisphosphatase 1 (Gene Name=FBP1)

[Back to BioLiP]