Structure of PDB 1bi9 Chain A
Receptor sequence
>1bi9A (length=478) Species:
10116
(Rattus norvegicus) [
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MASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEV
QEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAT
LATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIPVDGDYF
TFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSA
LYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGK
LIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQC
CTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYN
KILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIF
GPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTV
WINCYGEFGLREYSEVKTVTVKIPQKNS
3D structure
PDB
1bi9
The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.
Chain
A
Resolution
2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB)
N169 K192 E268 C302 E399
Catalytic site (residue number reindexed from 1)
N168 K191 E267 C301 E398
Enzyme Commision number
1.2.1.36
: retinal dehydrogenase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
NAD
A
I165 I166 W168 K192 A194 E195 G225 G229 A230 F243 S246 V249
I164 I165 W167 K191 A193 E194 G224 G228 A229 F242 S245 V248
Gene Ontology
Molecular Function
GO:0001758
retinal dehydrogenase activity
GO:0004028
3-chloroallyl aldehyde dehydrogenase activity
GO:0004029
aldehyde dehydrogenase (NAD+) activity
GO:0016491
oxidoreductase activity
GO:0016620
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016918
retinal binding
Biological Process
GO:0001568
blood vessel development
GO:0001822
kidney development
GO:0001889
liver development
GO:0002138
retinoic acid biosynthetic process
GO:0003007
heart morphogenesis
GO:0006629
lipid metabolic process
GO:0007494
midgut development
GO:0008283
cell population proliferation
GO:0008284
positive regulation of cell population proliferation
GO:0008285
negative regulation of cell population proliferation
GO:0009855
determination of bilateral symmetry
GO:0009952
anterior/posterior pattern specification
GO:0009954
proximal/distal pattern formation
GO:0010628
positive regulation of gene expression
GO:0014032
neural crest cell development
GO:0016331
morphogenesis of embryonic epithelium
GO:0021915
neural tube development
GO:0021983
pituitary gland development
GO:0030182
neuron differentiation
GO:0030324
lung development
GO:0030326
embryonic limb morphogenesis
GO:0030900
forebrain development
GO:0030902
hindbrain development
GO:0031016
pancreas development
GO:0031076
embryonic camera-type eye development
GO:0032355
response to estradiol
GO:0032526
response to retinoic acid
GO:0033189
response to vitamin A
GO:0034097
response to cytokine
GO:0035115
embryonic forelimb morphogenesis
GO:0035799
ureter maturation
GO:0042572
retinol metabolic process
GO:0042573
retinoic acid metabolic process
GO:0042574
retinal metabolic process
GO:0042904
9-cis-retinoic acid biosynthetic process
GO:0043010
camera-type eye development
GO:0043065
positive regulation of apoptotic process
GO:0048384
retinoic acid receptor signaling pathway
GO:0048566
embryonic digestive tract development
GO:0048738
cardiac muscle tissue development
GO:0051289
protein homotetramerization
GO:0060324
face development
GO:0071300
cellular response to retinoic acid
GO:1905562
regulation of vascular endothelial cell proliferation
Cellular Component
GO:0005737
cytoplasm
GO:0048471
perinuclear region of cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1bi9
,
PDBe:1bi9
,
PDBj:1bi9
PDBsum
1bi9
PubMed
10320326
UniProt
Q63639
|AL1A2_RAT Retinal dehydrogenase 2 (Gene Name=Aldh1a2)
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