Structure of PDB 1bf5 Chain A

Receptor sequence
>1bf5A (length=545) Species: 9606 (Homo sapiens) [Search protein sequence]
LDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHLLL
KKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIG
GPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ
VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLV
KLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGS
LAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLE
TTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLS
EVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENIND
KNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTF
LLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIR
NYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRGYIKTELISVS
3D structure
PDB1bf5 Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T327 H328 K336 V339 T419 E421 N460 V461 T178 H179 K187 V190 T270 E272 N311 V312
BS02 dna A R378 K413 E421 V426 T427 S459 N460 Q463 R229 K264 E272 V277 T278 S310 N311 Q314
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1bf5, PDBe:1bf5, PDBj:1bf5
PDBsum1bf5
PubMed9630226
UniProtP42224|STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (Gene Name=STAT1)

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