Structure of PDB 1bdg Chain A

Receptor sequence
>1bdgA (length=444) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
FSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIK
MFPSYVTKTPNGTETGNFLALDLGGTNYRVLSVTLEGGKSPRIQERTYCI
PAEKMSGSGTELFKYIAETLADFLENNGMKDKKFDLGFTFSFPCVQKGLT
HATLVRWTKGFSADGVEGHNVAELLQTELDKRELNVKCVAVVNDTVGTLA
SCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVINTEWGAF
GEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLV
EQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVP
VVEPIDNRIVRYACEMVVKRAAYLAGAGIACILRRINRSEVTVGVDGSLY
KFHPKFCERMTDMVDKLKPKNTRFCLRLSEDGSGKGAAAIAASC
3D structure
PDB1bdg The structure of mammalian hexokinase-1.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R91 S155 R170 D209
Catalytic site (residue number reindexed from 1) R79 S141 R156 D194
Enzyme Commision number 2.7.1.1: hexokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A S155 F156 T172 K173 N208 D209 G233 N235 E260 E294 S141 F142 T158 K159 N193 D194 G218 N220 E246 E280
Gene Ontology
Molecular Function
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 D-glucose binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0019318 hexose metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1bdg, PDBe:1bdg, PDBj:1bdg
PDBsum1bdg
PubMed9665168
UniProtQ26609|HXK_SCHMA Hexokinase

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