Structure of PDB 1b4p Chain A

Receptor sequence
>1b4pA (length=217) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PMILGYWNVRGLTHPIRLLLEYTDSSYEEKRYAMGDAPDYDRSQWLNEKF
KLGLDFPNLPYLIDGSRKITQSNAIMRYLARKHHLCGETEEERIRVDVLE
NQAMDTRLQLAMVCYSPDFERKKPEYLEGLPEKMKLYSEFLGKQPWFAGN
KITYVDFLVYDVLDQHRIFEPKCLDAFPNLKDFVARFEGLKKISDYMKSG
RFLSKPIFAKMAFWNPK
3D structure
PDB1b4p The Three-Dimensional Structure of a Glutathione S-Transferease from the Mu Gene Class. Structural Analysis of the Binary Complex of Isoenzyme 3-3 and Glutathione at 2.2-A Resolution
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y6 L12 R17
Catalytic site (residue number reindexed from 1) Y6 L12 R17
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GPS A Y6 W7 V9 G11 R42 W45 K49 N58 L59 Q71 S72 Y115 F208 A209 Y6 W7 V9 G11 R42 W45 K49 N58 L59 Q71 S72 Y115 F208 A209
BS02 GPS A L20 E21 D24 S25 S26 Y27 E28 E29 R201 L20 E21 D24 S25 S26 Y27 E28 E29 R201
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005102 signaling receptor binding
GO:0005504 fatty acid binding
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007608 sensory perception of smell
GO:0010038 response to metal ion
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014070 response to organic cyclic compound
GO:0018916 nitrobenzene metabolic process
GO:0033595 response to genistein
GO:0042178 xenobiotic catabolic process
GO:0043651 linoleic acid metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0070458 cellular detoxification of nitrogen compound
GO:0071313 cellular response to caffeine
GO:0098869 cellular oxidant detoxification
GO:1902168 response to catechin
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016529 sarcoplasmic reticulum
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1b4p, PDBe:1b4p, PDBj:1b4p
PDBsum1b4p
PubMed
UniProtP08010|GSTM2_RAT Glutathione S-transferase Mu 2 (Gene Name=Gstm2)

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