Structure of PDB 1b3n Chain A

Receptor sequence
>1b3nA (length=411) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAG
LVKDFNCEDIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIG
AAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIVNMVAGHLTIMYG
LRGPSISIATACTSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGG
FGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGA
KIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGYVN
AHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESI
YSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFG
GTNGSLIFKKI
3D structure
PDB1b3n Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C163 H303 E314 K335 H340 F398 F400
Catalytic site (residue number reindexed from 1) C162 H302 E313 K334 H339 F397 F399
Enzyme Commision number 2.3.1.179: beta-ketoacyl-[acyl-carrier-protein] synthase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CER A G107 I108 A162 C163 E191 F202 H303 G399 F400 G106 I107 A161 C162 E190 F201 H302 G398 F399
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0009409 response to cold
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0044281 small molecule metabolic process
GO:1903966 monounsaturated fatty acid biosynthetic process
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1b3n, PDBe:1b3n, PDBj:1b3n
PDBsum1b3n
PubMed10037680
UniProtP0AAI5|FABF_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 2 (Gene Name=fabF)

[Back to BioLiP]