Structure of PDB 1b11 Chain A

Receptor sequence
>1b11A (length=113) Species: 11673 (Feline immunodeficiency virus) [Search protein sequence]
VGTTTTLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGR
QNMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIQPLLG
RDNMIKFNIRLVM
3D structure
PDB1b11 Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3TL A G32 D34 M56 I57 G58 G29 D31 M53 I54 G55 MOAD: Ki=41nM
PDBbind-CN: -logKd/Ki=7.39,Ki=41nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1b11, PDBe:1b11, PDBj:1b11
PDBsum1b11
PubMed10651036
UniProtP16088|POL_FIVPE Pol polyprotein (Gene Name=pol)

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